Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T cell senescence and CAR-T cell exhaustion in hematological malignancies

4 Jul 2018

Abstract excerpt

T cell senescence has been recognized to play an immunosuppressive role in the aging population and cancer patients. Strategies dedicated to preventing or reversing replicative and premature T cell senescence are required to increase the lifespan of human beings and to reduce the morbidity from cancer. In addition, overcoming the T cell terminal differentiation or senescence from lymphoma and leukemia patients is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29973238
DOI: 10.1186/s13045-018-0629-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T cell senescence and CAR-T cell exhaustion in hematological malignanciesPMID 29973238Read ↗

Characteristics and mechanisms of T‐cell senescence: A potential target for cancer immunotherapySemantic proximity Read ↗

Counteracting CAR T cell dysfunctionSemantic proximity Read ↗

Are immunosenescent T cells really senescent?Semantic proximity Read ↗

Cellular senescence: a double-edged sword in cancer therapySemantic proximity Read ↗

Senolytic CAR T Cells in Solid Tumors and Age-Related PathologiesSemantic proximity Read ↗

Immunosenescence: a key player in cancer developmentSemantic proximity Read ↗

T-cell Senescence in the Tumor MicroenvironmentSemantic proximity Read ↗

T-cell senescence: A crucial player in autoimmune diseasesSemantic proximity Read ↗

Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospectsSemantic proximity Read ↗

Exploiting tumor cell senescence in anticancer therapySemantic proximity Read ↗

Therapy-Induced Senescence: Novel Approaches for Markers IdentificationSemantic proximity Read ↗

Cellular senescence: a promising strategy for cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.