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Comparison of enzymatic and bisulfite conversion of circulating cell-free tumor DNA for DNA methylation analyses

4 Jun 2025

Abstract excerpt

BACKGROUND: Detection of DNA methylation biomarkers in circulating cell-free DNA (cfDNA) has great clinical potential for cancer management, but there is a high need for method optimization and standardization. Bisulfite conversion of DNA is the gold-standard pre-treatment method for DNA methylation analyses, but causes also DNA fragmentation and loss. Enzymatic conversion of DNA represents a promising...

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PMID: 40468374
DOI: 10.1186/s13148-025-01901-4

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