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Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood

14 Sept 2023

Abstract excerpt

BACKGROUND: DNA methylation biomarkers in circulating cell-free DNA (cfDNA) have great clinical potential for cancer management. Most methods for DNA methylation analysis require bisulfite conversion, causing DNA degradation and loss. This is particularly challenging for cfDNA, which is naturally fragmented and normally present in low amounts. The aim of the present study was to identify an optimal combination of...

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PMID: 37710283
DOI: 10.1186/s13148-023-01563-0

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