Article
Detection of rare mutations, copy number alterations, and methylation in the same template DNA molecules.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2023
Wang Yuxuan, Douville Christopher, Cohen Joshua D, Mattox Austin, Curtis Sam, Silliman Natalie, Popoli Maria, Ptak Janine, Dobbyn Lisa, Nehme Nadine, Dudley Jonathan C, Summers Mahmoud, Zhang Ming, Ho-Pham Lan T, Tran Bich N H, Tran Thach S, Nguyen Tuan V, Bettegowda Chetan, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert
Abstract excerpt
The analysis of cell-free DNA (cfDNA) from plasma offers great promise for the earlier detection of cancer. At present, changes in DNA sequence, methylation, or copy number are the most sensitive ways to detect the presence of cancer. To further increase the sensitivity of such assays with limited amounts of sample, it would be useful to be able to evaluate the same template molecules for all these changes. Here,...
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