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Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA

4 Jan 2023

Abstract excerpt

BACKGROUND: Epigenetic variants carried by circulating tumor DNA can be used as biomarkers for early detection of hepatocellular carcinoma (HCC) by noninvasive liquid biopsy. However, traditional methylation analysis method, bisulfite sequencing, with disadvantages of severe DNA damage, is limited in application of low-amount cfDNA analysis. RESULTS: Through mild enzyme-mediated conversion, enzymatic methyl...

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PMID: 36600275
DOI: 10.1186/s13148-022-01420-6

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