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Article

CPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage.

Oncoimmunology - 1 Jan 2024

Wei Rongyuan, Song Junquan, Pan Hongda, Liu Xiaowen, Gao Jianpeng

Abstract excerpt

Cancer-associated fibroblasts (CAFs) exhibit remarkable phenotypic heterogeneity, with specific subsets implicated in immunosuppression in various malignancies. However, whether and how they attenuate anti-tumor immunity in gastric cancer (GC) remains elusive. CPT1C, a unique isoform of carnitine palmitoyltransferase pivotal in regulating fatty acid oxidation, is briefly indicated as a protumoral metabolic...

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Share to Cancer-Associated Fibroblasts
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Immune Tolerance

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Source

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Identifiers

PMID: 38746869
DOI: 10.1080/2162402X.2024.2352179
PMCID: PMC11093039

Genes

CPT1C
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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