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Article

Efficient and multiplexed somatic genome editing with Cas12a mice.

Nature biomedical engineering - 1 Nov 2025

Hebert Jess D, Xu Haiqing, Tang Yuning J, Ruiz Paloma A, Detrick Colin R, Wang Jing, Hughes Nicholas W, Donosa Oscar, Siah Vicky P, Andrejka Laura, Karmakar Saswati, Aboiralor Irenosen, Tang Rui, Sotillo Rocio, Sage Julien, Cong Le, Petrov Dmitri A, Winslow Monte M

Abstract excerpt

Somatic genome editing in mouse models has increased our understanding of the in vivo effects of genetic alterations. However, existing models have a limited ability to create multiple targeted edits, hindering our understanding of complex genetic interactions. Here we generate transgenic mice with Cre-regulated and constitutive expression of enhanced Acidaminococcus sp. Cas12a (enAsCas12a), which robustly...

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Identifiers

PMID: 40447760
DOI: 10.1038/s41551-025-01407-7
PMCID: PMC12502729

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