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Article

Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms.

Biology of sex differences - 25 Oct 2017

Lindén Magdalena, Ramírez Sepúlveda Jorge I, James Tojo, Thorlacius Gudny Ella, Brauner Susanna, Gómez-Cabrero David, Olsson Tomas, Kockum Ingrid, Wahren-Herlenius Marie

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) are autoimmune disorders characterized by autoantibodies, dysregulated B cells, and notably high female-to-male incidence ratios. Genome-wide association studies have identified several susceptibility SNPs for both diseases. Many SNPs in the genome are expression quantitative trait loci (eQTLs), with context-dependent effects....

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Source

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Identifiers

PMID: 29070082
DOI: 10.1186/s13293-017-0153-7
PMCID: PMC5657123

Genes

ARCN1
BLK
CTSB
CXCR5
DHX9
INPP1
NCF2
PHRF1
PXK
SNRPC
TNIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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