A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions

Abstract excerpt

Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence evaluation methods rely mainly on limited markers or homogeneous samples, which might fail to capture universal senescence features, limiting their generalizability. Here we developed the human universal senescence index...

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• Share to Advanced biosensing and bioanalysis techniques
• Share to Single-cell and spatial transcriptomics
• Share to Telomeres, Telomerase, and Senescence