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A multidimensional systems biology analysis of cellular senescence in aging and disease

7 Apr 2020

Abstract excerpt

BACKGROUND: Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many genes play a role in cellular senescence, yet a comprehensive understanding of its pathways is still lacking. RESULTS: We develop CellAge (http://genomics.senescence.info/cells), a manually curated database of 279 human genes driving...

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Share to Epigenetics and DNA Methylation
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PMID: 32264951
DOI: 10.1186/s13059-020-01990-9

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