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Article

Fast intratumor heterogeneity inference from single-cell sequencing data.

Nature computational science - 1 Sept 2022

Kızılkale Can, Rashidi Mehrabadi Farid, Sadeqi Azer Erfan, Pérez-Guijarro Eva, Marie Kerrie L, Lee Maxwell P, Day Chi-Ping, Merlino Glenn, Ergün Funda, Buluç Aydın, Sahinalp S Cenk, Malikić Salem

Abstract excerpt

We introduce HUNTRESS, a computational method for mutational intratumor heterogeneity inference from noisy genotype matrices derived from single-cell sequencing data, the running time of which is linear with the number of cells and quadratic with the number of mutations. We prove that, under reasonable conditions, HUNTRESS computes the true progression history of a tumor with high probability. On simulated and...

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Identifiers

PMID: 38177468
DOI: 10.1038/s43588-022-00298-x
PMCID: PMC10765963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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