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IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner

27 May 2025

Abstract excerpt

Primordial germ cells (PGCs) are specified early during embryogenesis and establish the germ cell lineage for transmitting genetic and epigenetic information from parents to offspring. However, whether N 6 -methyladenosine (m 6 A)-mediated epigenetic regulation is involved in the specification of PGCs remains elusive. In this study, we report that a knockout of m 6 A writers or overexpression of m 6 A erasers...

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PMID: 40436019
DOI: 10.1016/j.stem.2025.05.001

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