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H3K18 lactylation-mediated Ythdf2 activation restrains mouse female germline stem cell proliferation via promoting Ets1 mRNA degradation

27 May 2025

Abstract excerpt

Germline stem cells are critical for sustaining fertility by balancing self-renewal and differentiation, and are regulated by genetic and epigenetic programs. Although extensively investigated, the rare female germline stem cells (FGSCs) in mammalian ovaries hinder their application in regenerative medicine. The N 6 -methyladenosine (m 6 A) reader YTHDF2 is required for female germ cell competence. However, the...

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PMID: 40426273
DOI: 10.1186/s13148-025-01890-4

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