Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules

Abstract excerpt

<h4>ABSTRACT</h4> Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among TPD approaches, Proteolysis Targeting Chimeras (PROTACs) have shown marked advancement with numerous candidates in clinical development. Despite their potential, most PROTACs utilize advanced small...

Topics

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• Drug Discovery
• Molecular Structure
• Peptidase Inhibition and Analysis
• Phenotype
• Photolysis
• Protein Degradation and Inhibitors
• Proteolysis
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

8ebd3365-136a-5b1f-9e20-984ec0846ced

DOI

10.1101/2025.03.21.644652