Nitroreduction is not involved in the genotoxicity of 2-nitropropane in cultured mammalian cells.

doi:10.1093/mutage/6.1.87

Back to search

Article

Nitroreduction is not involved in the genotoxicity of 2-nitropropane in cultured mammalian cells.

Mutagenesis - 1 Jan 1991

Haas-Jobelius M, Ziegler-Skylakakis K, Andrae U

Abstract excerpt

We have investigated the importance of nitroreduction for the genotoxicity of the carcinogen 2-nitropropane (2-NP) in primary cultures of rat hepatocytes and in V79 Chinese hamster cells. Induction of DNA repair synthesis was used as an indicator of genotoxic effects in hepatocytes. Genotoxicity...

Topics

Acetone
Animals
Cell Line
Cells, Cultured
Cricetinae
Cricetulus
DNA
DNA Repair
Drug Resistance
Liver
Micronucleus Tests
Mutagenicity Tests
Mutation
Nitrites
Nitroparaffins
Oxidation-Reduction
Propane
Rats

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.