Article
A multiple end-point approach to evaluation of cytotoxicity and genotoxicity of erythrosine (FD and C Red No. 3) in a V79 hepatocyte-mediated mutation assay.
Mutation research - 1 Jan 2000
Rogers C G, Boyes B G, Matula T I, Héroux-Metcalf C, Clayson D B
Abstract excerpt
V79 Chinese hamster lung cells were used to evaluate in vitro the cytotoxicity and genotoxicity of erythrosine (2', 4', 5', 7'-tetraiodofluorescein disodium salt; FD and C Red No. 3), a color additive used widely in foods, drugs and cosmetics. Erythrosine reduced colony size at 200 micrograms/ml...
Topics
- Animals
- Biotransformation
- Cell Survival
- Cricetinae
- DNA Damage
- Dose-Response Relationship, Drug
- Erythrosine
- Fluoresceins
- In Vitro Techniques
- Microsomes, Liver
- Mitosis
- Mutagenicity Tests
- Mutation
- Sister Chromatid Exchange