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Article

APOL4-mediated intracellular cholesterol trafficking is essential for glioblastoma cell growth

21 May 2025

Abstract excerpt

BACKGROUND: Dysregulated fatty acid metabolism is a key contributor to poor prognosis in glioma, and targeting cholesterol metabolism represents a promising therapeutic strategy. Apolipoprotein L4 (APOL4), a member of the Apolipoprotein L family, has been implicated in lipid metabolism, but its role in glioma remains unclear. METHODS: RNA-sequencing were performed to analysis gene expression under exogenous...

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PMID: 40399861
DOI: 10.1186/s12885-025-14316-4

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