Article

LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1

2019-02-03

Abstract excerpt

Cholesterol is a critical component of membranes and a precursor for hormones and other signaling molecules. Previously, we showed that unlike astrocytes, glioblastoma cells do not downregulate cholesterol synthesis when plated at high density. In this report, we show that high cell density induces ABCA1 expression in glioblastoma cells, enabling them to get rid of excess cholesterol generated by an activated chol...

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Literature Corpus work: bf7cc1c4-0bba-52f3-9f76-0e3d0b2d3c9d
DOI: 10.1101/539221

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