Article
In vivo functional characterization of EGFR variants identifies novel drivers of glioblastoma.
Neuro-oncology - 14 Mar 2023
Yu Kwanha, Kong Kathleen, Lozzi Brittney, Luna-Figueroa Estefania, Cervantes Alexis, Curry Rachel, Mohila Carrie A, Rao Ganesh, Jalali Ali, Mills Gordon B, Scott Kenneth L, Deneen Benjamin
Abstract excerpt
BACKGROUND: Glioblastoma is the most common and aggressive primary brain tumor. Large-scale sequencing initiatives have cataloged its mutational landscape in hopes of elucidating mechanisms driving this deadly disease. However, a major bottleneck in harnessing this data for new therapies is deciphering "driver" and "passenger" events amongst the vast volume of information. METHODS: We utilized an autochthonous,...
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