Article

Microglial lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerability

2026-04-28

Abstract excerpt

Glioblastoma (GBM) is characterized by diffuse infiltration into the surrounding brain, which precludes complete surgical resection, the strongest determinant of patient survival. The mechanisms that drive this invasive growth remain incompletely understood. Here we identify a lipid-mediated paracrine signaling axis through which microglia, the resident macrophages of the brain, promote glioma invasion. Integratin...

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Identifiers and source

Literature Corpus work: 87b0ffcb-6e0a-5cb3-9c8d-cae85f4baf05
DOI: 10.64898/2026.04.24.720633

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