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Exploratory analysis of the proteomic profile in plasma in adults with Down syndrome in the context of Alzheimer's disease

1 Mar 2025

Abstract excerpt

INTRODUCTION: Adults with Down syndrome (DS) show increased risk for Alzheimer's disease (AD) due to the triplication of chromosome 21 encoding the amyloid precursor protein gene. Further, this triplication possibly contributes to dysregulation of the immune system, furthering AD pathophysiology. METHODS: Using Olink Explore 3072, we measured ∼3000 proteins in plasma from 73 adults with DS and 15 euploid, healthy...

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PMID: 40110647
DOI: 10.1002/alz.70040

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