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Risk of Alzheimer's disease in Down syndrome: Insights gained by multi‐omics

1 Apr 2025

Abstract excerpt

Individuals with Down syndrome (DS) are highly susceptible to Alzheimer's disease (AD). The integration of genomics, transcriptomics, epigenomics, proteomics, and metabolomics enables unprecedented understanding of DS-AD, offering a detailed picture of this complex issue. The vast -omics data also present challenges that reflect the complexity of genetic information flow. These studies nonetheless reveal critical...

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PMID: 40207399
DOI: 10.1002/alz.14604

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