Article
Ubiquitous L1 mosaicism in hippocampal neurons.
Cell - 9 Apr 2015
Upton Kyle R, Gerhardt Daniel J, Jesuadian J Samuel, Richardson Sandra R, Sánchez-Luque Francisco J, Bodea Gabriela O, Ewing Adam D, Salvador-Palomeque Carmen, van der Knaap Marjo S, Brennan Paul M, Vanderver Adeline, Faulkner Geoffrey J
Abstract excerpt
Somatic LINE-1 (L1) retrotransposition during neurogenesis is a potential source of genotypic variation among neurons. As a neurogenic niche, the hippocampus supports pronounced L1 activity. However, the basal parameters and biological impact of L1-driven mosaicism remain unclear. Here, we performed single-cell retrotransposon capture sequencing (RC-seq) on individual human hippocampal neurons and glia, as well...
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