Article

Interactions of the LINE-1 encoded ORF1p with proteins and chromatin converge on a role in neuronal physiology

2025-09-09

Abstract excerpt

Retrotransposons are emerging as novel regulators of embryonic and brain development. We recently demonstrated that the LINE-1–encoded protein ORF1p is abundantly expressed in adult mouse and human neurons, although its function remains unclear. Here, we characterize the ORF1p interactome in differentiated mouse and human neurons using mass spectrometry and identify novel partners implicated in gene regulation and...

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Literature Corpus work: d13b6706-aafb-5e84-8fed-cacdc2c693cb
DOI: 10.1101/2025.09.05.674414

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