Article

Combinatorial effects of gene dosage, polygenic background and environment on complex traits

2026-05-01

Abstract excerpt

Complex traits arise from the combined effects of rare and common genetic variation, development and environment, but resolving their joint contributions has been limited by statistical power. Here, we meta-analyze effects of recurrent copy number variants (CNVs), polygenic scores, sex, age and medications on height and body mass index in 1,447,001 individuals across 6 biobanks and clinical cohorts. CNVs show larg...

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Literature Corpus work: ec4c3b67-e6f1-55aa-aa5a-ccf87da6ab28
DOI: 10.64898/2026.04.30.26352063

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