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Article

A Multivariable Mendelian Randomization Study of Systolic and Diastolic Blood Pressure, Lipid Profile, and Heart Failure Subtypes.

Genes - 27 Aug 2024

Liu Chang, Hui Qin, Wells Quinn S, Farber-Eger Eric, Gaziano John Michael, Wilson Peter W F, Quyyumi Arshed A, Vaccarino Viola, Hu Yi-Juan, Benkeser David, The Million Veteran Program, Phillips Lawrence S, Joseph Jacob, Sun Yan V

Abstract excerpt

Heart failure (HF) is a significant health burden, with two major clinical subtypes: HF with reduced (HFrEF) and preserved ejection fraction (HFpEF). Blood pressure and lipid profile are established risk factors of HF. We performed univariable and multivariable Mendelian randomization (MR) analyses to assess potential causal effects of blood pressures and lipids on HF subtypes. Genetic instruments for blood...

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Identifiers

PMID: 39336717
DOI: 10.3390/genes15091126
PMCID: PMC11431108

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