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Article

Inflammatory-lipid residual risk phenotypes delineate the HFpEF probability spectrum independent of cardiometabolic mediation.

BMC cardiovascular disorders - 29 Apr 2026

Chen Chunmei, Zhang Siqi, Liu Yuetong, Zhao Lu, Wang Yuxin, Li Yumeng, Song Qingqiao

Abstract excerpt

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized as a systemic syndrome characterized by chronic low-grade inflammation, metabolic dysregulation, and microvascular dysfunction. Although residual inflammatory risk and residual cholesterol risk have each been associated with adverse cardiovascular outcomes, their joint relationship with HFpEF probability spectrum, and...

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Topics

Humans
Heart Failure
Cross-Sectional Studies
Phenotype
Female
Stroke Volume

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biomarkers

Male

Inflammation

C-Reactive Protein

Aged

Middle Aged

Risk Factors

Inflammation Mediators

Risk Assessment

Cholesterol, LDL

Cardiometabolic Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 42056889
DOI: 10.1186/s12872-026-05836-3
PMCID: PMC13528071

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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