A polygenetic rat model of divergent aerobic capacity reveals a liver-brain interaction impacting Alzheimer's disease-like phenotypes.

doi:10.1113/JP286750

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Article

A polygenetic rat model of divergent aerobic capacity reveals a liver-brain interaction impacting Alzheimer's disease-like phenotypes.

The Journal of physiology - 1 Mar 2026

Lysaker Colton R, Kugler Benjamin A, Csikos Vivien, Birky Cole J, Gilmore Caleb A, Wenger Madi, Franczak Edziu, Davis Xin, Hauger Brittany M, Allen Julie A, Troutwine Benjamin R, Gonzalez-Duran Laura, McCoin Colin S, Chauhan Munish, Harris Janna L, Frazier Alexandria L, Winter Michelle K, Koch Lauren G, Britton Steven L, Thyfault John P, Wilkins Heather M

Abstract excerpt

The interaction between liver and brain health is an emerging complex relationship implicated in Alzheimer's disease (AD). Divergence in aerobic capacity influences liver and brain health independently; however, whether these factors converge to influence AD risk is mechanistically unknown. Bile acid metabolism has been implicated as a link between liver and brain health and is modulated by aerobic capacity....

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PMID: 40349321
DOI: 10.1113/JP286750
PMCID: PMC13127301

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