Article

Identifying differences in bile acid pathways for cholesterol clearance in Alzheimer’s disease using metabolic networks of human brain regions

2019-09-26

Abstract excerpt

Alzheimer’s disease (AD) is the leading cause of dementia, with metabolic dysfunction seen years before the emergence of clinical symptoms. Increasing evidence suggests a role for primary and secondary bile acids, the end-product of cholesterol metabolism, influencing pathophysiology in AD. In this study, we analyzed transcriptomes from 2114 post-mortem brain samples from three independent cohorts and identified t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20e49768-7738-5565-acf8-e75d14320d1a
DOI: 10.1101/782987

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying differences in bile acid pathways for cholesterol clearance in Alzheimer’s disease using metabolic networks of human brain regionsDOI 10.1101/782987Read

Functional biological paths altered in Alzheimer’s disease: from genes to bile acidsSemantic proximity Read

Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut MicrobiomeSemantic proximity Read

Expert insights: The potential role of the gut microbiome‐bile acid‐brain axis in the development and progression of Alzheimer's disease and hepatic encephalopathySemantic proximity Read

Towards understanding brain-gut-microbiome connections in Alzheimer’s diseaseSemantic proximity Read

Integration of proteomics and metabolomics – insights into inflammation, metabolic dysregulation, and vascular aspects in ADSemantic proximity Read

Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's diseaseSemantic proximity Read

Cell type-specific master metabolic regulators of Alzheimer’s diseaseSemantic proximity Read

Gut microbiota-driven metabolic alterations reveal gut–brain communication in Alzheimer’s disease model miceSemantic proximity Read

Sets of Co-regulated Serum Lipids are Associated with Alzheimer Disease PathophysiologySemantic proximity Read

Identification of key lipid metabolism-related genes in Alzheimer’s diseaseSemantic proximity Read

Pathway-based integration of multi-omics data reveals lipidomics alterations validated in an Alzheimer’s Disease mouse model and risk loci carriersSemantic proximity Read

Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriersSemantic proximity Read