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Article

Matrix Softness Induces an Afibrogenic Lipofibroblast Phenotype in Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology - 1 Nov 2025

Berhan Asres, Gunatilaka Avanka, Lee Chiaohwei, Zhang Stephanie, Tan Daniel, Harris Trudi, Jaffar Jade, Jativa Fernando, Lönnstedt Ingrid, Alhamdoosh Monther, Ng Milica, Langenbach Shenna, Varshney Swati, Williamson Nicholas A, Lee Peter V S, Wilson Nick, Gao Bryan, Westall Glen, Stewart Alastair G

Abstract excerpt

Contractile myofibroblasts immersed in stiffened remodeled extracellular matrix characterize fibrotic lesions in idiopathic pulmonary fibrosis. Lipofibroblasts are lipid droplet-containing interstitial fibroblasts that support functional homeostasis of the developing and adult lung. We show that stiff substrates augment myofibroblast differentiation and extracellular matrix production in vitro under basal...

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PMID: 40343813
DOI: 10.1165/rcmb.2025-0030OC

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