The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans.

doi:10.1093/g3journal/jkaf102

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The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 6 Aug 2025

Valenzuela-Villatoro Marina, Gómez-Orte Eva, Guerrero-Gómez David, Cheng Qing, Zheleva Angelina, Mora-Lorca José Antonio, Petrovic Dunja, O Neil Nigel J, Cerón Julián, Hatakeyama Akiko, Onami Shuichi, Ordóñez-Luque Alexandra, Ayuso Cristina, Askjaer Peter, Filipovic Milos R, Arnér Elias S J, Cabello Juan, Miranda-Vizuete Antonio

Abstract excerpt

The gsr-1 gene encodes the only glutathione reductase in Caenorhabditis elegans and gsr-1 loss-of-function alleles have a fully penetrant embryonic lethal phenotype. Therefore, maintenance of glutathione redox homeostasis is essential for nematode survival. We report here that impairment of the nonsense-mediated mRNA decay (NMD) pathway suppresses the embryonic lethality of gsr-1 mutants, allowing their normal...

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PMID: 40333285
DOI: 10.1093/g3journal/jkaf102
PMCID: PMC12341920

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