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Article

Mitochondrial and cytoplasmic thioredoxin reductase variants encoded by a single Drosophila gene are both essential for viability.

The Journal of biological chemistry - 29 Mar 2002

Missirlis Fanis, Ulschmid Julia K, Hirosawa-Takamori Mitsuko, Grönke Sebastian, Schäfer Ulrich, Becker Katja, Phillips John P, Jäckle Herbert

Abstract excerpt

Defense against oxidative stress in mammals includes the regeneration of the major thiol reductants glutathione and thioredoxin by glutathione reductase and thioredoxin reductase (TrxR), respectively. In contrast, Drosophila, and possibly insects in general, lacks glutathione reductase and must rely solely on the TrxR system. The mammalian TrxRs described so far are selenoproteins that utilize NADPH to reduce...

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Identifiers

PMID: 11796729
DOI: 10.1074/jbc.M111692200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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