Article
Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster.
Science (New York, N.Y.) - 26 Jan 2001
Kanzok S M, Fechner A, Bauer H, Ulschmid J K, Müller H M, Botella-Munoz J, Schneuwly S, Schirmer R, Becker K
Abstract excerpt
The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly conserved among bacteria, fungi, worms, and mammals. These proteins maintain intracellular redox homeostasis to protect the organism from oxidative damage. Here we demonstrate the absence of glutathione reductase in Drosophila melanogaster, identify a new type of thioredoxin reductase, and provide evidence that a thioredoxin...
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