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Article

Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans.

Mechanisms of ageing and development - 1 Oct 2009

Khare Shilpi, Gomez Tara, Linster Carole L, Clarke Steven G

Abstract excerpt

We have shown that Caenorhabditis elegans lacking the PCM-1 protein repair l-isoaspartyl methyltransferase are more sensitive to oxidative stress than wild-type nematodes. Exposure to the redox-cycling quinone juglone upon exit from dauer diapause results in defective egg-laying (Egl phenotype) in the pcm-1 mutants only. Treatment with paraquat, a redox-cycling dipyridyl, causes a more severe developmental delay...

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Identifiers

PMID: 19682488
DOI: 10.1016/j.mad.2009.08.002
PMCID: PMC2757507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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