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Article

Role of MTL-1, MTL-2, and CDR-1 in mediating cadmium sensitivity in Caenorhabditis elegans.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Aug 2012

Hall Julie, Haas Kathryn L, Freedman Jonathan H

Abstract excerpt

Cadmium is an environmental toxicant whose exposure is associated with multiple human pathologies. To prevent cadmium-induced toxicity, organisms produce a variety of detoxification molecules. In response to cadmium, the nematode Caenorhabditis elegans increases the steady-state levels of several hundred genes, including two metallothioneins, mtl-1 and mtl-2, and the cadmium-specific response gene, cdr-1. Despite...

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Identifiers

PMID: 22552775
DOI: 10.1093/toxsci/kfs166
PMCID: PMC3493192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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