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Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes.

Archives of biochemistry and biophysics - 15 Dec 1997

Kagan R M, Niewmierzycka A, Clarke S

Abstract excerpt

The methylation of abnormal L-isoaspartyl residues by protein L-isoaspartate (D-aspartate) O-methyltransferase (EC 2.1.1.77) can lead to their conversion to L-aspartyl residues. For polypeptides damaged by spontaneous reactions that generate L-isoaspartyl residues, these steps represent a protein repair pathway that can limit the accumulation of potentially detrimental proteins in the aging process. We report...

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PMID: 9434744
DOI: 10.1006/abbi.1997.0362

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