Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes.

doi:10.1006/abbi.1997.0362

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Article

Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes.

Archives of biochemistry and biophysics - 15 Dec 1997

Kagan R M, Niewmierzycka A, Clarke S

Abstract excerpt

The methylation of abnormal L-isoaspartyl residues by protein L-isoaspartate (D-aspartate) O-methyltransferase (EC 2.1.1.77) can lead to their conversion to L-aspartyl residues. For polypeptides damaged by spontaneous reactions that generate L-isoaspartyl residues, these steps represent a protein...

Topics

Alleles
Animals
Caenorhabditis elegans
Chromosome Mapping
DNA Transposable Elements
Disorders of Sex Development
Electrophoresis, Polyacrylamide Gel
Fertility
Gene Targeting
Humans
Larva
Longevity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylation

Mutagenesis, Insertional

Peptides

Polymerase Chain Reaction

Protein D-Aspartate-L-Isoaspartate Methyltransferase

Protein Methyltransferases

Source

Open in PubMed

Identifiers

PMID: 9434744
DOI: 10.1006/abbi.1997.0362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9434744-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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