Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease

Abstract excerpt

Abstract Celiac disease is an autoimmune disorder in which ingestion of dietary gluten triggers an immune reaction in the small intestine leading to destruction of the lining epithelium. Current treatment focusses on lifelong adherence to a gluten-free diet. Gluten-specific CD4 + T cells and cytotoxic intraepithelial CD8 + T cells have been proposed to be central in disease pathogenesis. Here we use unbiased...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Atherosclerosis and Cardiovascular Diseases
• Share to Celiac Disease Research and Management
• Share to Galectins and Cancer Biology