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Article

Effect of hydrogen sulfide on alpha-synuclein aggregation and cell viability.

Scientific reports - 4 May 2025

Ostrakhovitch Elena A, Song Eun-Suk, Stegemann Johannah E, McLeod Michael, Yamasaki Tritia R

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by nigrostriatal degeneration and aggregation of α-synuclein (α-Syn) with accumulation of insoluble aggregates in Lewy bodies. Familial mutations in α-Syn are associated with the development of PD. Accumulation of insoluble aggregates results in neuronal toxicity. Identification of compounds that inhibit seeding activity...

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Identifiers

PMID: 40320462
DOI: 10.1038/s41598-025-99794-z
PMCID: PMC12050307

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