Article
The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein.
Nature communications - 29 Oct 2021
Sun Yunpeng, Long Houfang, Xia Wencheng, Wang Kun, Zhang Xia, Sun Bo, Cao Qin, Zhang Yaoyang, Dai Bin, Li Dan, Liu Cong
Abstract excerpt
α-Synuclein (α-Syn) can form different fibril strains with distinct polymorphs and neuropathologies, which is associated with the clinicopathological variability in synucleinopathies. How different α-syn fibril strains are produced and selected under disease conditions remains poorly understood. In this study, we show that the hereditary mutation G51D induces α-syn to form a distinct fibril strain in vitro. The...
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