Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

doi:10.1073/pnas.1606791113

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Article

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

Proceedings of the National Academy of Sciences of the United States of America - 18 Oct 2016

Villar-Piqué Anna, Lopes da Fonseca Tomás, Sant'Anna Ricardo, Szegö Éva Mónika, Fonseca-Ornelas Luis, Pinho Raquel, Carija Anita, Gerhardt Ellen, Masaracchia Caterina, Abad Gonzalez Enrique, Rossetti Giulia, Carloni Paolo, Fernández Claudio O, Foguel Debora, Milosevic Ira, Zweckstetter Markus, Ventura Salvador, Outeiro Tiago Fleming

Abstract excerpt

Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant neuronal protein that can adopt different conformations and biological properties. Recently, aSyn pathology was shown to spread between neurons in a prion-like manner. Proteins like aSyn that exhibit self-propagating capacity appear to be able to adopt different...

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PMID: 27708160
DOI: 10.1073/pnas.1606791113
PMCID: PMC5081623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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