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Article

Environmental Risk Factors Are Associated With the Natural History of Familial Dilated Cardiomyopathy.

Journal of the American Heart Association - 6 May 2025

Peters Stacey A, Wright Leah, Yao Jess, McCall Lauren, Thompson Tina, Thompson Bryony, Johnson Renee, Huynh Quan, Santiago Celine F, Trainer Alison, Perrin Mark, James Paul, Zentner Dominica, Kalman Jon, Marwick Thomas H, Fatkin Diane

Abstract excerpt

BACKGROUND: Familial dilated cardiomyopathy (DCM) is characterized by marked variability in phenotypic penetrance. The extent to which this is determined by patient-specific environmental factors is unknown. METHODS AND RESULTS: A retrospective longitudinal cohort study was performed in families with DCM-causing genetic variants. Environmental factors were classified into 2 subsets based on evidence for a causal...

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Identifiers

PMID: 40314344
DOI: 10.1161/JAHA.124.037311
PMCID: PMC12184215

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