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Article

The Complex and Diverse Genetic Architecture of Dilated Cardiomyopathy.

Circulation research - 14 May 2021

Hershberger Ray E, Cowan Jason, Jordan Elizabeth, Kinnamon Daniel D

Abstract excerpt

Our insight into the diverse and complex nature of dilated cardiomyopathy (DCM) genetic architecture continues to evolve rapidly. The foundations of DCM genetics rest on marked locus and allelic heterogeneity. While DCM exhibits a Mendelian, monogenic architecture in some families, preliminary data from our studies and others suggests that at least 20% to 30% of DCM may have an oligogenic basis, meaning that...

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Identifiers

PMID: 33983834
DOI: 10.1161/CIRCRESAHA.121.318157
PMCID: PMC8158434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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