Article
Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences.
European heart journal - 7 Jan 2021
Verdonschot Job A J, Merlo Marco, Dominguez Fernando, Wang Ping, Henkens Michiel T H M, Adriaens Michiel E, Hazebroek Mark R, Masè Marco, Escobar Luis E, Cobas-Paz Rafael, Derks Kasper W J, van den Wijngaard Arthur, Krapels Ingrid P C, Brunner Han G, Sinagra Gianfranco, Garcia-Pavia Pablo, Heymans Stephane R B
Abstract excerpt
AIMS: The dilated cardiomyopathy (DCM) phenotype is the result of combined genetic and acquired triggers. Until now, clinical decision-making in DCM has mainly been based on ejection fraction (EF) and NYHA classification, not considering the DCM heterogenicity. The present study aimed to identify patient subgroups by phenotypic clustering integrating aetiologies, comorbidities, and cardiac function along cardiac...
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