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Article

Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies.

JAMA cardiology - 1 Nov 2025

Maamari Dimitri J, Biddinger Kiran J, Jurgens Sean J, Rämö Joel T, Gaziano Liam, Zheng Alice, Challa Saketh P, Hayes Dolphurs, Gongora Carlos A, Choi Seung Hoan, Chang Kyong-Mi, Tsao Philip S, Arany Zoltan, Thavendiranathan Paaladinesh, Huffman Jennifer E, Fahed Akl C, Sarma Amy A, Neilan Tomas G, Khera Amit V, Ellinor Patrick T, Aragam Krishna G

Abstract excerpt

Importance: Rare monogenic variants linked to nonischemic dilated cardiomyopathy (DCM) are enriched among individuals with secondary cardiomyopathies, such as peripartum (PPCM), alcohol-induced (ACM), and cancer therapy-related (CCM) cardiomyopathies. However, it remains unclear whether a polygenic predisposition to DCM also contributes to these conditions. Objective: To assess the association of a DCM polygenic...

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Identifiers

PMID: 41032333
DOI: 10.1001/jamacardio.2025.3248
PMCID: PMC12489798

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