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Article

CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein.

Journal of biomedical science - 28 Apr 2013

Terui Hiroko, Akagi Kiwamu, Kawame Hiroshi, Yura Kei

Abstract excerpt

BACKGROUND: Lynch syndrome is a hereditary cancer predisposition syndrome caused by a mutation in one of the DNA mismatch repair (MMR) genes. About 24% of the mutations identified in Lynch syndrome are missense substitutions and the frequency of missense variants in MSH6 is the highest amongst these MMR genes. Because of this high frequency, the genetic testing was not effectively used in MSH6 so far. We,...

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Identifiers

PMID: 23621914
DOI: 10.1186/1423-0127-20-25
PMCID: PMC3651391

Genes

MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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