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Identification of SNPs in hMSH3/MSH6 interaction domain affecting the structure and function of MSH2 protein.

Biotechnology and applied biochemistry - 1 Dec 2022

Singh Sidhartha, Sharma Siddharth, Baranwal Manoj

Abstract excerpt

MutS homolog 2 (MSH2) is a mismatch repair gene that plays a critical role in DNA repair pathways, and its mutations are associated with different cancers. The present study aimed to find out the single nucleotide polymorphisms (SNPs) of MSH2 protein associated with causing structural and functional changes leading to the development of cancer with the help of computational tools. Four different tools for...

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PMID: 34837403
DOI: 10.1002/bab.2295

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