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Elucidating the Role of MLL1 nsSNPs: Structural and Functional Alterations and Their Contribution to Hematological Malignancies Susceptibility

2023-10-05

Abstract excerpt

The MLL1 gene located on chromosome 11q23, is crucial for histone lysine-specific methylation and is frequently implicated in various leukemia types. Despite prior in silico investigations into non-synonymous single nucleotide polymorphisms (nsSNPs) associated with leukemia in the MLL1 gene, there is a dearth of comprehensive studies evaluating their impact on the protein's structure, function, and post-trans...

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Literature Corpus work
b1dde5e3-7d73-5fa5-acd0-62c1b30b0ab9
DOI
10.20944/preprints202310.0282.v1
Open publication

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Elucidating the Role of MLL1 nsSNPs: Structural and Functional Alterations and Their Contribution to Hematological Malignancies SusceptibilityDOI 10.20944/preprints202310.0282.v1
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