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Article

Elucidating the role of MLL1 nsSNPs: Structural and functional alterations and their contribution to leukemia development.

PloS one - 1 Jan 2024

Al-Nakhle Hakeemah H, Yagoub Hind S, Alrehaili Rahaf Y, Shaqroon Ola A, Khan Minna K, Alsharif Ghaidaa S

Abstract excerpt

(1) BACKGROUND: The Mixed lineage leukemia 1 (MLL1) gene, located on chromosome 11q23, plays a pivotal role in histone lysine-specific methylation and is consistently associated with various types of leukemia. Non-synonymous Single Nucleotide Polymorphisms (nsSNPs) have been tied to numerous diseases, including cancers, and have become valuable cancer biomarkers. There's a notable gap in studies probing the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39405275
DOI: 10.1371/journal.pone.0304986
PMCID: PMC11478856

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