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Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia

13 Dec 2012

Abstract excerpt

The identification of new genetic lesions in chronic lymphocytic leukemia (CLL) prompts a comprehensive and dynamic prognostic algorithm including gene mutations and chromosomal abnormalities and their changes during clonal evolution. By integrating mutational and cytogenetic analysis in 1274 CLL samples and using both a training-validation and a time-dependent design, 4 CLL subgroups were hierarchically...

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PMID: 23243274
DOI: 10.1182/blood-2012-09-458265

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