Article
Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.
Blood - 7 Jun 2018
Kleinstern Geffen, Camp Nicola J, Goldin Lynn R, Vachon Celine M, Vajdic Claire M, de Sanjose Silvia, Weinberg J Brice, Benavente Yolanda, Casabonne Delphine, Liebow Mark, Nieters Alexandra, Hjalgrim Henrik, Melbye Mads, Glimelius Bengt, Adami Hans-Olov, Boffetta Paolo, Brennan Paul, Maynadie Marc, McKay James, Cocco Pier Luigi, Shanafelt Tait D, Call Timothy G, Norman Aaron D, Hanson Curtis, Robinson Dennis, Chaffee Kari G, Brooks-Wilson Angela R, Monnereau Alain, Clavel Jacqueline, Glenn Martha, Curtin Karen, Conde Lucia, Bracci Paige M, Morton Lindsay M, Cozen Wendy, Severson Richard K, Chanock Stephen J, Spinelli John J, Johnston James B, Rothman Nathaniel, Skibola Christine F, Leis Jose F, Kay Neil E, Smedby Karin E, Berndt Sonja I, Cerhan James R, Caporaso Neil, Slager Susan L
Abstract excerpt
Inherited loci have been found to be associated with risk of chronic lymphocytic leukemia (CLL). A combined polygenic risk score (PRS) of representative single nucleotide polymorphisms (SNPs) from these loci may improve risk prediction over individual SNPs. Herein, we evaluated the association of a PRS with CLL risk and its precursor, monoclonal B-cell lymphocytosis (MBL). We assessed its validity and...
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